*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KD1923000
CHEMICAL NAME           : 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)
                          furan-1,11(2H)-dione, 5,6,9,17,19,21-
                          hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl
                          -8-(N-1-piperazinylfo rmimidoyl)-, 21- acetate
CAS REGISTRY NUMBER     : 13292-45-0
BEILSTEIN REFERENCE NO. : 0603769
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C42-H56-N4-O12
MOLECULAR WEIGHT        : 809.02
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * AF/AP
   * Demethylrifampicin
   * N-Demethyl-rifampicin
   * 4-N-Demethylrifampicin
   * N-Demethylrifampin
   * 3-((1-Piperazinylimino)methyl)rifampicin
   * Rifampicin AF/AP
   * Rifampicin, 3-((1-piperazinylimino)methyl)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   38KLAC "Structure-Activity Relationship among the Semisynthetic
   Antibiotics,"  Perlman, D., ed., New York, Academic Press, 1977
   Volume(issue)/page/year: -,531,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 695 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CMTRAG Chemotherapia.  (Basel, Switzerland)  V.1-12, 1960-67.  For publisher
   information, see CHTHBK.  Volume(issue)/page/year: 12,155,1967
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 100 mg/L
REFERENCE :
   BBRCA9 Biochemical and Biophysical Research Communications.  (Academic
   Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1959-
   Volume(issue)/page/year: 60,96,1974
 
                            *** END OF RECORD ***