*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KB4725000
CHEMICAL NAME           : 10H-3,10a-Epidithiopyrazino(1,2-a)indole-1,4-dione,
                          2,3,5a,6-hydroxy-3- (hydroxymethyl)-2-methyl-,
                          (3R-(3-alpha,5a-beta,6-beta,10a-alpha))-
CAS REGISTRY NUMBER     : 67-99-2
BEILSTEIN REFERENCE NO. : 0050675
REFERENCE               : 4-27-00-08902 (Beilstein Handbook Reference)
LAST UPDATED            : 199709
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C13-H14-N2-O4-S2
MOLECULAR WEIGHT        : 326.41
WISWESSER LINE NOTATION : T C6 B566/JO A 2BJ O AVN JXSS NNV EU GU MHTT&&J DQ
                          M1Q N
COMPOUND DESCRIPTOR     : Agricultural Chemical
                          Drug
                          Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Aspergillin
   * Gliotoxin
   * S.N. 12870
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   VHTODE Veterinary and Human Toxicology.  (American College of Veterinary and
   Comparative Toxicology, Publication Office, Comparative Toxicology,
   Manhattan, KS 66506)  V.19-    1977-  Volume(issue)/page/year:
   32(Suppl),63,1990
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
   JACSAT Journal of the American Chemical Society.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1879-  Volume(issue)/page/year: 65,2005,1943
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 67 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CMTRAG Chemotherapia.  (Basel, Switzerland)  V.1-12, 1960-67.  For publisher
   information, see CHTHBK.  Volume(issue)/page/year: 10,12,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 32 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CMTRAG Chemotherapia.  (Basel, Switzerland)  V.1-12, 1960-67.  For publisher
   information, see CHTHBK.  Volume(issue)/page/year: 10,12,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CMTRAG Chemotherapia.  (Basel, Switzerland)  V.1-12, 1960-67.  For publisher
   information, see CHTHBK.  Volume(issue)/page/year: 10,12,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CMTRAG Chemotherapia.  (Basel, Switzerland)  V.1-12, 1960-67.  For publisher
   information, see CHTHBK.  Volume(issue)/page/year: 10,12,1965
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   JACSAT Journal of the American Chemical Society.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1879-  Volume(issue)/page/year: 65,2005,1943
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   VHTODE Veterinary and Human Toxicology.  (American College of Veterinary and
   Comparative Toxicology, Publication Office, Comparative Toxicology,
   Manhattan, KS 66506)  V.19-    1977-  Volume(issue)/page/year:
   32(Suppl),63,1990
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 250 mg/L
REFERENCE :
   MYCPAH Mycopathologia.  (Kluwer Academic Pub. Group, Distribution Centre,
   POB 322, 3300 AH Dordrecht, Netherlands)  V.1-    1938-
   Volume(issue)/page/year: 87,43,1984
 
                            *** END OF RECORD ***