*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KB2600000
CHEMICAL NAME           : Ephedrine, hydrogen sulfate
CAS REGISTRY NUMBER     : 73986-87-5
LAST UPDATED            : 198706
DATA ITEMS CITED        : 12
MOLECULAR FORMULA       : C10-H15-N-O.H2-O4-S
MOLECULAR WEIGHT        : 263.34
WISWESSER LINE NOTATION : QYR&Y1&M1 &..H2.S-O4
SYNONYMS/TRADE NAMES :
   * Ephedrine sulfate
   * alpha-(1-(Methylamino)ethyl)benzyl alcohol hydrogen sulfate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 135 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
REFERENCE :
   MEDEAJ Medecine (Paris).  (Paris, France)  V.1-40, 1919-59.  Discontinued.
   Volume(issue)/page/year: 9,59,1930
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   MEDEAJ Medecine (Paris).  (Paris, France)  V.1-40, 1919-59.  Discontinued.
   Volume(issue)/page/year: 9,59,1930
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 31600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#03164
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   MEDEAJ Medecine (Paris).  (Paris, France)  V.1-40, 1919-59.  Discontinued.
   Volume(issue)/page/year: 9,59,1930
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
REFERENCE :
   MEDEAJ Medecine (Paris).  (Paris, France)  V.1-40, 1919-59.  Discontinued.
   Volume(issue)/page/year: 9,59,1930
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 590 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   MEDEAJ Medecine (Paris).  (Paris, France)  V.1-40, 1919-59.  Discontinued.
   Volume(issue)/page/year: 9,59,1930
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 310 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   MEDEAJ Medecine (Paris).  (Paris, France)  V.1-40, 1919-59.  Discontinued.
   Volume(issue)/page/year: 9,59,1930
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   MEDEAJ Medecine (Paris).  (Paris, France)  V.1-40, 1919-59.  Discontinued.
   Volume(issue)/page/year: 9,59,1930
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 66 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   MEDEAJ Medecine (Paris).  (Paris, France)  V.1-40, 1919-59.  Discontinued.
   Volume(issue)/page/year: 9,59,1930
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 340 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   MEDEAJ Medecine (Paris).  (Paris, France)  V.1-40, 1919-59.  Discontinued.
   Volume(issue)/page/year: 9,59,1930
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
REFERENCE :
   MEDEAJ Medecine (Paris).  (Paris, France)  V.1-40, 1919-59.  Discontinued.
   Volume(issue)/page/year: 9,59,1930
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 530 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   MEDEAJ Medecine (Paris).  (Paris, France)  V.1-40, 1919-59.  Discontinued.
   Volume(issue)/page/year: 9,59,1930
 
                            *** END OF RECORD ***