*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KA8082000
CHEMICAL NAME           : Enterotoxin, clostridium perfringens, type A
LAST UPDATED            : 199209
DATA ITEMS CITED        : 6
COMPOUND DESCRIPTOR     : Natural Product
SYNONYMS/TRADE NAMES :
   * Clostridium perfringens (welchii) type A enterotoxin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 ug/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - respiratory depression
   Nutritional and Gross Metabolic - changes in phosphorus
REFERENCE :
   TOXIA6 Toxicon.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
   UK)  V.1-    1962-  Volume(issue)/page/year: 29,751,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 39 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJBCAI European Journal of Biochemistry.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.1-    1967-
   Volume(issue)/page/year: 149,287,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 81160 ng/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   INFIBR Infection and Immunity.  (American Soc. for Microbiology, 1913 I St.,
   NW, Washington, DC 20006)  V.1-    1970-  Volume(issue)/page/year:
   12,440,1975
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 14560 ng/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   JCVPAR Journal of Comparative Pathology.  (Academic Press, Inc., 1 E. First
   St., Duluth, MN 55802) V.75-    1965-  Volume(issue)/page/year: 83,265,1973
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 29130 ng/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   JCVPAR Journal of Comparative Pathology.  (Academic Press, Inc., 1 E. First
   St., Duluth, MN 55802) V.75-    1965-  Volume(issue)/page/year: 83,265,1973
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - domestic
DOSE/DURATION           : 12900 ng/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JCVPAR Journal of Comparative Pathology.  (Academic Press, Inc., 1 E. First
   St., Duluth, MN 55802) V.75-    1965-  Volume(issue)/page/year: 83,265,1973
 
                            *** END OF RECORD ***