*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : JO6150000
CHEMICAL NAME           : 1,3,2-Dithiastibolane-4,5-dicarboxylic acid,
                          2,2'-((1,2-dicarboxy-1,2-ethanediyl)bis(thio)) bis-,
                          hexasodium salt
CAS REGISTRY NUMBER     : 3064-61-7
OTHER CAS REGISTRY NOS. : 133-94-8
LAST UPDATED            : 199712
DATA ITEMS CITED        : 29
MOLECULAR FORMULA       : C12-H6-O12-S6-Sb2.6Na
MOLECULAR WEIGHT        : 915.98
WISWESSER LINE NOTATION : T5S-SB-STJ DVO EVO BSYVO&YVO&S- BT5S-SB-STJ DVO EVO
                          &-NA- 6
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Antimony dimercaptosuccinate
   * Antimony dimercaptosuccinate(IV)
   * Astiban
   * Ro 4-1544/6
   * Sb-58
   * Sodium antimony-2,3-meso-dimercaptosuccinate
   * Stibocaptate
   * TWSb
   * Twsb/6
   * WR 7035
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 195 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CHTHBK Chemotherapy (Basel).  (S. Karger Pub., Inc., 79 Fifth Ave., New
   York, NY 10003) V.13-    1968-  Volume(issue)/page/year: 13,339,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAZMAE Fortschritte der Arzneimittelforschung.  Progress in Drug Research.
   (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way,
   Secaucus, NJ 07094)  V.1-    1959-  Volume(issue)/page/year: 17,108,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BWHOA6 Bulletin of the World Health Organization.  (WHO, Pub. Center USA, 49
   Sheridan Ave., Albany, NY 12210)  Volume(issue)/page/year: 45,371,1971

                              *** REVIEWS ***
 
   ACGIH TLV-TWA 0.5 mg(Sb)/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   MSHA STANDARD-air:TWA 0.5 mg(Sb)/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year: 3,15,1971

   OSHA PEL (Gen Indu):8H TWA 0.5 mg(Sb)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1910.1000,1994

   OSHA PEL (Construc):8H TWA 0.5 mg(Sb)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1926.55,1994

   OSHA PEL (Shipyard):8H TWA 0.5 mg(Sb)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1915.1000,1993

   OSHA PEL (Fed Cont):8H TWA 0.5 mg(Sb)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   41,50-204.50,1994

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-ARAB Republic of Egypt:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-AUSTRALIA:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-AUSTRIA:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-BELGIUM:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-DENMARK:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-FINLAND:.TWA  (0.5 mg(Sb)/m3) JAN 1993
   
   OEL-FRANCE:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-GERMANY:TWA 0.5 mg(Sb)/m3 (total dust) JAN 1993
   
   OEL-HUNGARY:STEL 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-THE NETHERLANDS:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-THE PHILIPPINES:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-POLAND:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-RUSSIA:TWA 0.2 mg(Sb)/m3;STEL 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-SWEDEN:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-SWITZERLAND:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-TURKEY:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO ANTIMONY-air:10H TWA 0.5 mg(Sb)/m3
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

 
                            *** END OF RECORD ***