*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : IO1450000
CHEMICAL NAME : 5,9:7,10a-Dimethano-10aH-(1,3)dioxocino(6,5-d)pyrimid
ine-4,7,10,11,12-pent ol, octahydro-
12-(hydroxymethyl)-2-imino-
CAS REGISTRY NUMBER : 4368-28-9
OTHER CAS REGISTRY NOS. : 11005-69-9
12626-86-7
BEILSTEIN REFERENCE NO. : 0049176
REFERENCE : 4-27-00-08206 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 19
MOLECULAR FORMULA : C11-H17-N3-O8
MOLECULAR WEIGHT : 319.31
WISWESSER LINE NOTATION : T66 B6 D6/B-H/DM A B- C 2BD M AO B-O DX EMYMTJ CQ EQ
GQ G1Q JQ LUM
COMPOUND DESCRIPTOR : Natural Product
SYNONYMS/TRADE NAMES :
* Fugu poison
* Maculotoxin
* Spheroidine
* Tarichatoxin
* Tetrodontoxin
* Tetrodotoxin
* Tetrodoxin
* TTX
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 15 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
144,1100,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 334 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin
Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo
150, Japan) V.1- 1960- Volume(issue)/page/year: 14,186,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
144,1100,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 4,331,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 7300 ng/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin
Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo
150, Japan) V.1- 1960- Volume(issue)/page/year: 14,186,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intracerebral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 600 ng/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
REFERENCE :
SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin
Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo
150, Japan) V.1- 1960- Volume(issue)/page/year: 14,186,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8700 pg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IGAYAY Igaku No Ayumi. Progress in Medicine. (Ishiyaku Shuppan K.K.,
1-7-10, Honkomagom, Bunkyo-ku, Tokyo, Japan) V.1- 1946-
Volume(issue)/page/year: 112,861,1980
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 7500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HXPHAU Handbuch der Experimentellen Pharmakologie. (Berlin, Ger.) New
series: V.1-49, 1935-78. For publisher information, see HEPHD2.
Volume(issue)/page/year: 6,63,1938
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 650 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HXPHAU Handbuch der Experimentellen Pharmakologie. (Berlin, Ger.) New
series: V.1-49, 1935-78. For publisher information, see HEPHD2.
Volume(issue)/page/year: 6,63,1938
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HXPHAU Handbuch der Experimentellen Pharmakologie. (Berlin, Ger.) New
series: V.1-49, 1935-78. For publisher information, see HEPHD2.
Volume(issue)/page/year: 6,63,1938
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HXPHAU Handbuch der Experimentellen Pharmakologie. (Berlin, Ger.) New
series: V.1-49, 1935-78. For publisher information, see HEPHD2.
Volume(issue)/page/year: 6,63,1938
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intracerebral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 25 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HXPHAU Handbuch der Experimentellen Pharmakologie. (Berlin, Ger.) New
series: V.1-49, 1935-78. For publisher information, see HEPHD2.
Volume(issue)/page/year: 6,63,1938
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 4 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HXPHAU Handbuch der Experimentellen Pharmakologie. (Berlin, Ger.) New
series: V.1-49, 1935-78. For publisher information, see HEPHD2.
Volume(issue)/page/year: 6,63,1938
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraspinal
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 80 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HXPHAU Handbuch der Experimentellen Pharmakologie. (Berlin, Ger.) New
series: V.1-49, 1935-78. For publisher information, see HEPHD2.
Volume(issue)/page/year: 6,63,1938
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 14 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory
change
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
UK) V.1- 1962- Volume(issue)/page/year: 5,25,1967
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 15 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
144,1100,1964
*** REVIEWS ***
TOXICOLOGY REVIEW
TRBMAV Texas Reports on Biology and Medicine. (Galveston, TX) V.1-41(2),
1943-81/82. Discontinued. Volume(issue)/page/year: 33,183,1975
*** STATUS IN U.S. ***
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***