*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : IM4360000
CHEMICAL NAME           : Diisopropylamine, N-nitroso-
CAS REGISTRY NUMBER     : 601-77-4
BEILSTEIN REFERENCE NO. : 0635986
REFERENCE               : 4-04-00-03388 (Beilstein Handbook Reference)
LAST UPDATED            : 199709
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C6-H14-N2-O
MOLECULAR WEIGHT        : 130.22
WISWESSER LINE NOTATION : 1Y1&NNO&&Y1&1
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Diethylamine, 1,1'-dimethyl-N-nitroso-
   * Diisopropylnitrosamin
   * Diisopropyl-N-nitrosamine
   * N-Nitrosodiisopropylamine
   * 2-Propanamine, N-(1-methylethyl)-N-nitroso-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 850 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZEKBAI Zeitschrift fuer Krebsforschung.  (Berlin, Fed. Rep. Ger.)  V.1-75,
   1903-71.  For publisher information, see JCROD7.  Volume(issue)/page/year:
   69,103,1967
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 14 gm/kg/110W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Blood - tumors
REFERENCE :
   ZEKBAI Zeitschrift fuer Krebsforschung.  (Berlin, Fed. Rep. Ger.)  V.1-75,
   1903-71.  For publisher information, see JCROD7.  Volume(issue)/page/year:
   69,103,1967
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1800 mg/kg/50W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 62,407,1979
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 300 ug/well
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 260,349,1991

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-GERMANY;Carcinogen JAN 1993
   
   OEL-SWITZERLAND;Carcinogen JAN 1993

                          *** STATUS IN U.S. ***
 
   OSHA ANALYTICAL METHOD #38

 
                            *** END OF RECORD ***