*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : JI4730000
CHEMICAL NAME           : 1,3-Dioxolo(4,5-g)isoquinoline,
                          7-methyl-5-(2-methylbutyl)-, hydrochloride
CAS REGISTRY NUMBER     : 17105-22-5
LAST UPDATED            : 198502
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C16-H19-N-O2.Cl-H
MOLECULAR WEIGHT        : 293.82
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1-(2-Methylbutyl)-3-methyl-6,7-methylenedioxyisoquinoline hydrochloride
   * 7-Methyl-5-(2-methylbutyl)-1,3-dioxolo(4,5-g)isoquinoline hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 315 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 88,1197,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 55 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 88,1197,1968
 
                            *** END OF RECORD ***