*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : JH4920000
CHEMICAL NAME           : 5H,12H-3,4-Dioxa-5a,11a,15a-triazacyclooct(lm)indeno(
                          5,6-b)fluorene-11,15( 2H,13H)-dione, 1,
                          10,10a,14,14a,15b-hexahydro-10,10a-dihydroxy-7-methox
                          y-2,2-dimethyl-5-(2-m ethyl-1-propenyl)-,
                          (5R-(5-alpha,10-alpha,10a-alpha,14a-alpha-15b-alpha))
                          -
CAS REGISTRY NUMBER     : 12771-72-1
LAST UPDATED            : 199304
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C27-H33-N3-O7
MOLECULAR WEIGHT        : 511.63
COMPOUND DESCRIPTOR     : Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * TR1
   * Verruculogen
   * Verruculogen TR 1
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 127 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 41,1868,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2400 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 41,1868,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2400 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   41KEAL "Toxicology, Biochemistry and Pathology of Mycotoxins," Uraguchi, K.
   and M. Yamazaki, eds., New York, John Wiley & Sons, Inc., 1978
   Volume(issue)/page/year: -,108,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 266 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 41,1868,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 15200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 41,1868,1988

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
   
   EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test

 
                            *** END OF RECORD ***