*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : JH2830000
CHEMICAL NAME           : 1,6-Dioxaspiro(4.5)decane-7-butyric acid,
                          2-(5-ethyltetrahydro-5-(tetrahydro-3-methyl-5-
                          (tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-
                          2H-pyran-2-yl)-2-fury l)-2-furyl)-9-
                          hydroxy-beta-methoxy-alpha,gamma,2,8-tetramethyl-,
                          monosodium salt
CAS REGISTRY NUMBER     : 22373-78-0
OTHER CAS REGISTRY NOS. : 22136-43-2
LAST UPDATED            : 199710
DATA ITEMS CITED        : 14
MOLECULAR FORMULA       : C36-H61-O11.Na
MOLECULAR WEIGHT        : 692.96
WISWESSER LINE NOTATION : T6OXTJ DQ E1 FY1&YO1&Y1&VQ B-& BT5OXTJ E1 E- ET5OTJ
                          B2 B- BT5OTJ
SYNONYMS/TRADE NAMES :
   * Coban
   * Coban 45
   * Monensin, monosodium salt
   * Monensin sodium
   * Monensin sodium salt
   * Rumensin
   * Sodium monensin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 29 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JANSAG Journal of Animal Science.  (American Soc. of Animal Science, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1942-  Volume(issue)/page/year:
   58,1512,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 44 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 36,1195,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >10 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JANSAG Journal of Animal Science.  (American Soc. of Animal Science, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1942-  Volume(issue)/page/year:
   58,1512,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : >160 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JANSAG Journal of Animal Science.  (American Soc. of Animal Science, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1942-  Volume(issue)/page/year:
   58,1512,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 42 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JANSAG Journal of Animal Science.  (American Soc. of Animal Science, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1942-  Volume(issue)/page/year:
   58,1512,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - pig
DOSE/DURATION           : 17 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JANSAG Journal of Animal Science.  (American Soc. of Animal Science, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1942-  Volume(issue)/page/year:
   58,1512,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 145 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - muscle weakness
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   MBIID4 MBI, Mediko Biologicheskaya Informatsiya.  Medical-Biological
   Information.  ("Ivana Vazova" No. 3, Sofia 1000, Bulgaria)  1967-
   Volume(issue)/page/year: (3),3,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cattle
DOSE/DURATION           : 26 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JANSAG Journal of Animal Science.  (American Soc. of Animal Science, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1942-  Volume(issue)/page/year:
   58,1512,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - horse, donkey
DOSE/DURATION           : 2 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JANSAG Journal of Animal Science.  (American Soc. of Animal Science, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1942-  Volume(issue)/page/year:
   58,1512,1984
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3412 mg/kg/13W-C
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   JANSAG Journal of Animal Science.  (American Soc. of Animal Science, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1942-  Volume(issue)/page/year:
   58,1512,1984
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 409 mg/kg/13W-C
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JANSAG Journal of Animal Science.  (American Soc. of Animal Science, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1942-  Volume(issue)/page/year:
   58,1512,1984
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 4550 mg/kg/13W-C
TOXIC EFFECTS :
   Musculoskeletal - other changes
   Related to Chronic Data - death
REFERENCE :
   JANSAG Journal of Animal Science.  (American Soc. of Animal Science, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1942-  Volume(issue)/page/year:
   58,1512,1984

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X1284
       No. of Facilities: 162 (estimated)
       No. of Industries: 1
       No. of Occupations: 9
       No. of Employees: 1463 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***