*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AR5910000
CHEMICAL NAME           : Aconitine, 3-acetyl-, hydrobromide
CAS REGISTRY NUMBER     : 78600-25-6
LAST UPDATED            : 198610
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C36-H49-N-O12.Br-H
MOLECULAR WEIGHT        : 768.78
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 3-Acetylaconitine, hydrobromide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 ug/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - local anesthetic
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - analgesia
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   2,82,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 700 ug/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - local anesthetic
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - analgesia
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   2,82,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1400 ug/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - local anesthetic
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - analgesia
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   2,82,1981
 
                            *** END OF RECORD ***