*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : HZ1755000
CHEMICAL NAME : Diesel exhaust
LAST UPDATED : 199712
DATA ITEMS CITED : 15
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
*** HEALTH HAZARD DATA ***
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3500 ug/m3/7H/2Y-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
11,546,1988
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3500 ug/m3/7H/78W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other oxidoreductases
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
11,546,1988
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 6 mg/m3/12H/3W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Immunological Including Allergic - decrease in cellular immune response
Immunological Including Allergic - increase in humoral immune response
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 116,227,1997
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 6300 ug/m3/20H/8W-I
TOXIC EFFECTS :
Cardiac - pulse rate
Lungs, Thorax, or Respiration - other changes
Lungs, Thorax, or Respiration - changes in lung weight
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 22,285,1980
** TUMORIGENIC DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4900 ug/m3/8H/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
DTESD7 52 Vanderbilt Ave., New York, NY 10017) V.1-15, 1977-87.
Discontinued 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977-
Volume(issue)/page/year: 13,349,1986
TYPE OF TEST : TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7 mg/m3/7H/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
9,208,1987
TYPE OF TEST : TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4 mg/m3/18H/2Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
DTESD7 52 Vanderbilt Ave., New York, NY 10017) V.1-15, 1977-87.
Discontinued 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977-
Volume(issue)/page/year: 13,459,1986
TYPE OF TEST : TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2500 ug/m3/18H/2Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
INHTE5 Inhalation Toxicology. (Hemisphere Publishing Corp., c/o Taylor &
Francis Inc., 1900 Frost Rd., Suite 101, Bristol, PA 19007) V.1- 1989-
Volume(issue)/page/year: 7,533,1995
** MUTATION DATA **
TYPE OF TEST : DNA adduct
ROUTE OF EXPOSURE : Inhalation
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 6200 ug/m3/16H/12W (Intermittent)
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
16,64,1990
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 46,41,1989
IARC Cancer Review:Human Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 46,41,1989
IARC Cancer Review:Group 2A
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 46,41,1989
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-GERMANY;Carcinogen JAN 1993
OEL-SWITZERLAND;Carcinogen JAN 1993
*** STATUS IN U.S. ***
NIOSH Analytical Method, 1996: Element carbon (diesel exhaust), 5040
*** END OF RECORD ***