*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : HQ6650000
CHEMICAL NAME : Dibenzylamine, N-(2-chloroethyl)-
CAS REGISTRY NUMBER : 51-50-3
BEILSTEIN REFERENCE NO. : 2213696
REFERENCE : 4-12-00-02180 (Beilstein Handbook Reference)
LAST UPDATED : 199706
DATA ITEMS CITED : 7
MOLECULAR FORMULA : C16-H18-Cl-N
MOLECULAR WEIGHT : 259.80
WISWESSER LINE NOTATION : G2N1R&1R
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Benzenemethanamine, N-(2-chloroethyl)-N-(phenylmethyl)-
* N-(2-Chloroethyl)dibenzylamine
* 2-(Dibenzylamino)ethyl chloride
* Dibenamine
* Dibenzyl chlorethylamine
* N,N-Dibenzyl-beta-chloroethylamine
* Dibenzyl(2-chloroethyl)amine
* SKF 199
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of
National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
Ont., Canada)
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHBUA9 Pharmaceutical Bulletin. (Tokyo, Japan) V.1-5, 1953-57. For
publisher information, see CPBTAL. Volume(issue)/page/year: 1,297,1953
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 395 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 155,69,1965
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 97,25,1949
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 105,317,1956
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE : 2 mg/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 12,346,1961
** MUTATION DATA **
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Intravaginal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 2 pph
REFERENCE :
JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428
E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year:
62,378,1974
*** END OF RECORD ***