*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HQ2860000
CHEMICAL NAME           : Dibenzo(b,e)thiepin-11-propylamine,
                          6,11-dihydro-N,N-dimethyl-, hydrochloride, hydrate
                          (2:2:1)
CAS REGISTRY NUMBER     : 846-54-8
LAST UPDATED            : 198710
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C19-H23-N-S.Cl-H.1/2H2-O
MOLECULAR WEIGHT        : 342.93
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 6,11-Dihydro-N,N-dimethyldibenzo(b,e)thiepin-11-propylamine hydrochloride 
    hydrate (2:2:1)
   * Hydrothiadene hydrochloride hemihydrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 36 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 15,524,1965
 
                            *** END OF RECORD ***