*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HQ1828000
CHEMICAL NAME           : Dibenzo(1,2,5)thiadiazepine,
                          6,11-dihydro-11-(3-(dimethylamino)propyl)-6-methyl-,
                          5,5- dioxide
CAS REGISTRY NUMBER     : 7200-23-9
LAST UPDATED            : 198305
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C17-H21-N3-O2-S
MOLECULAR WEIGHT        : 331.47
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   11-(3-(Dimethylamino)propyl)-6-methyl-6,11-dihydrodibenzo(1,2,5)thiadiaz
     epine 5,5-dioxide
   * 6-Methyl 11 (3-dimethylaminopropyl)dibenzo(c.f)(1,2,5)thiadiazepine  
   5,5-dioxyde
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 240 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 24,445,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 23 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 24,445,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 380 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 24,445,1966
 
                            *** END OF RECORD ***