*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HP3493000
CHEMICAL NAME           : Dibenzo-p-dioxin, 1,2,3,4-tetrachloro-
CAS REGISTRY NUMBER     : 30746-58-8
BEILSTEIN REFERENCE NO. : 1323932
REFERENCE               : 5-19-02-00040 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C12-H4-Cl4-O2
MOLECULAR WEIGHT        : 321.96
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * Dibenzo(b,e)(1,4)dioxin, 1,2,3,4-tetrachloro-
   * 1,2,3,4-Tetrachlorodibenzodioxin
   * 1,2,3,4-Tetrachlorodibenzo-para-dioxin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 38,879,1982
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 3320 ng/kg/26W-C
TOXIC EFFECTS :
   Blood - hemorrhage
   Skin and Appendages - hair
   Related to Chronic Data - death
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 15,401,1977

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Inadequate Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 15,41,1977

   IARC Cancer Review:Human No Adequate Data
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 15,41,1977

   IARC Cancer Review:Group 3
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,56,1987

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***