*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HP3310000
CHEMICAL NAME           : Dibenzo-p-dioxin, 1,2,3,7,8,9-hexachloro-
CAS REGISTRY NUMBER     : 19408-74-3
BEILSTEIN REFERENCE NO. : 1353896
REFERENCE               : 5-19-02-00042 (Beilstein Handbook Reference)
LAST UPDATED            : 199806
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C12-H2-Cl6-O2
MOLECULAR WEIGHT        : 390.84
WISWESSER LINE NOTATION : T C666 BO IOJ DG EG FG LG MG NG
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * D 70
   * 1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin
   * 1,2,3,7,8,9-Hexachlorodibenzo(b,e)(1,4)dioxin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1440 mg/kg
TOXIC EFFECTS :
   Endocrine - changes in spleen weight
   Endocrine - changes in thymus weight
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   44,335,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 60 ug/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   44,335,1978
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 120 pmol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 8,1485,1987

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Inadequate Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 15,41,1977

   IARC Cancer Review:Human No Adequate Data
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 15,41,1977

   IARC Cancer Review:Group 3
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 69,33,1997

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   On EPA IRIS database
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***