*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HO9800000
CHEMICAL NAME           : 5H-Dibenzo(a,d)cycloheptene-delta(sup
                          5),gamma-propylamine, 10,11-dihydro-N-methyl-
CAS REGISTRY NUMBER     : 72-69-5
BEILSTEIN REFERENCE NO. : 2216786
LAST UPDATED            : 199707
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C19-H21-N
MOLECULAR WEIGHT        : 263.41
WISWESSER LINE NOTATION : L C676 BY&T&J BU3M1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Amitryptyline, demethyl-
   * Avantyl
   * Aventyl
   * Demethylamitriptyline
   * Demethylamitryptyline
   * Desmethylamitriptyline
   *   10,11-Dihydro-N-methyl-5H-dibenzo(a,d)cycloheptene-delta(5,gamma)-propyl
     amine
   * 5-(3-Methylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene
   * Noramitriptyline
   * Nortriptyline
   * Nortryptiline
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 502 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - ataxia
   Behavioral - muscle contraction or spasticity
REFERENCE :
   HEPHD2 Handbook of Experimental Pharmacology.  (Springer-Verlag,
   Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.)  V.50-    1978-
   Volume(issue)/page/year: 55,527,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - ataxia
   Behavioral - muscle contraction or spasticity
REFERENCE :
   HEPHD2 Handbook of Experimental Pharmacology.  (Springer-Verlag,
   Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.)  V.50-    1978-
   Volume(issue)/page/year: 55,527,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 370 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 20,1561,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 6,338,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 17 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 17,65,1974

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   DICPBB Drug Intelligence and Clinical Pharmacy.  (POB 42435, Cincinnati, OH
   45242)  V.3-    1969-  Volume(issue)/page/year: 8,690,1974

   TOXICOLOGY REVIEW
   CLCHAU Clinical Chemistry (Winston-Salem, NC).  (American Assoc. for
   Clinical Chemistry, 1725 K St., NW, Washington, DC 20006)  V.1-    1955-
   Volume(issue)/page/year: 19,361,1973

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X4842
       No. of Facilities: 25 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 2440 (estimated)
       No. of Female Employees: 1459 (estimated)

 
                            *** END OF RECORD ***