*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HO9145500
CHEMICAL NAME           : 5H-Dibenzo(a,d)cycloheptene-5-propylamine,
                          10,11-dihydro-3-chloro-N,N-dimethyl-,
                          monohydrochloride
CAS REGISTRY NUMBER     : 3589-31-9
LAST UPDATED            : 199712
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C20-H24-Cl-N.Cl-H
MOLECULAR WEIGHT        : 350.36
WISWESSER LINE NOTATION : L C676&T&J B3N1&1 EG &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Chloramitriptyline hydrochloride
   *   3-Chloro-N,N-dimethyl-10,11-dihydro-5H-dibenzo(a,d)cycloheptene-5-propyl
     amine hydrochloride
   * 5H-Dibenzo(a,d)cycloheptene-5-propylamine,  
   3-chloro-10,11-dihydro-N,N-dimethyl-, HCl
   * L 572451 hydrochloride
   * VUFB3102
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - changes in motor activity (specific assay)
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   JMPCAS Journal of Medicinal and Pharmaceutical Chemistry.  (Washington, DC)
   V.1-5, 1959-62.  For publisher information, see JMCMAR.
   Volume(issue)/page/year: 4,411,1961
 
                            *** END OF RECORD ***