*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HO3300000
CHEMICAL NAME           : 5H-Dibenz(d,f)azonin-1-ol,
                          6,7,8,9-tetrahydro-2,12-dimethoxy-7-methyl-6-(2-pheny
                          lethyl)-, hydrochloride, (+-)-
CAS REGISTRY NUMBER     : 91574-89-9
LAST UPDATED            : 198910
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C27-H31-N-O3.Cl-H
MOLECULAR WEIGHT        : 454.05
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Asocainol hydrochloride
   * Go 4704A
   *   (+-)-6,7,8,9-Tetrahydro-2,12-dimethoxy-7-methyl-6-phenethyl-5H-dibenz(d,
     f)azonin-1-ol HCl
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 4,129,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 4,129,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 243 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 4,129,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 41 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 4,129,1986
 
                            *** END OF RECORD ***