*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HN4725000
CHEMICAL NAME           : Dibenz(a,h)anthracene, 5,6-epoxy-5,6-dihydro-
CAS REGISTRY NUMBER     : 1421-85-8
BEILSTEIN REFERENCE NO. : 1255733
REFERENCE               : 5-17-02-00551 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 17
MOLECULAR FORMULA       : C22-H14-O
MOLECULAR WEIGHT        : 294.36
WISWESSER LINE NOTATION : T E3 H6 D6 B666 FOT&T&&&J
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * DBA-5,6-epoxide
   * Dibenz(a,h)anthracene, 5,6-dihydro-5,6-epoxy-
   * Dibenz(a,h)anthracene 5,6 oxide
   * 5,6-Epoxy-5,6-dihydrodibenz(a,h)anthracene
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg/10W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 2,500,1967
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 300 ng/plate
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 16,787,1975
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 ug/plate
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 72,5135,1975
 
TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 4080 nmol/L
REFERENCE :
   NNBYA7 Nature (London), New Biology.  (Basingstoke, Hants., UK)  V.229-246,
   1971-73.  For publisher information, see NATUAS.  Volume(issue)/page/year:
   234,186,1971
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 1 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   38,2621,1978
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 500 ug/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   32,716,1972
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 1 mg/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   4,389,1971/1972
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 1 mg/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   4,389,1971/1972
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 2500 ug/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   32,1391,1972
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - hamster Kidney
DOSE/DURATION           : 5 mg/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   20,1297,1971
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 1 mg/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   4,389,1971/1972
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 1 mg/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   4,389,1971/1972

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; Histidine
   reversion-Ames test
   
   EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
   
   EPA GENETOX PROGRAM 1988, Positive/dose response: Cell transform.-mouse
   prostate
   
   EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
   
   EPA GENETOX PROGRAM 1988, Inconclusive: In vitro UDS-human fibroblast

 
                            *** END OF RECORD ***