*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HM2323000
CHEMICAL NAME           : 1,3,2-Diazaphosphorine,
                          hexahydro-2-(bis(2-chloroethyl)amino)-, 2-oxide
CAS REGISTRY NUMBER     : 20982-36-9
BEILSTEIN REFERENCE NO. : 0785235
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C7-H16-Cl2-N3-O-P
MOLECULAR WEIGHT        : 260.13
WISWESSER LINE NOTATION : T6MPMTJ BO BN2G2G
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * B 801
   * 2-(Bis(2-chloroethyl)amino)hexahydro-1,3,2-diazaphosphorine 2-oxide
   * N,N-Bis-(beta-chloroethyl)-N',N''-propylenephosphoricacidtriamide
   * Phosphoric triamide, cyclic N,N'-trimethylene N''-bis(2-chloroethyl)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,143,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTRRDO Cancer Treatment Reports.  (Washington, DC)  V.60-71, 1976-87.  For
   publisher information,  see JNCIEQ.  Volume(issue)/page/year: 60,477,1976
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   DRISAA Drosophila Information Service.  (Cold Spring Harbor Laboratory, POB
   100, Cold Spring Harbor, NY 11724)  No.1-    1934- Volume(issue)/page/year:
   41,102,1966

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal

 
                            *** END OF RECORD ***