*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HG4725000
CHEMICAL NAME           : Derris elliptica, root
LAST UPDATED            : 199603
DATA ITEMS CITED        : 7
COMPOUND DESCRIPTOR     : Agricultural Chemical
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Deguelia root
   * Derris resins
   * Derris root
   * Tuba root
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IECHAD Industrial and Engineering Chemistry.  (Washington, DC)  V.15-62,
   1923-70.  For publisher information, see CHMTBL.  Volume(issue)/page/year:
   28,815,1936
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 54,140,1943
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   IECHAD Industrial and Engineering Chemistry.  (Washington, DC)  V.15-62,
   1923-70.  For publisher information, see CHMTBL.  Volume(issue)/page/year:
   28,815,1936
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   IECHAD Industrial and Engineering Chemistry.  (Washington, DC)  V.15-62,
   1923-70.  For publisher information, see CHMTBL.  Volume(issue)/page/year:
   28,815,1936
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IECHAD Industrial and Engineering Chemistry.  (Washington, DC)  V.15-62,
   1923-70.  For publisher information, see CHMTBL.  Volume(issue)/page/year:
   28,815,1936
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 17600 mg/kg/16W-C
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   IECHAD Industrial and Engineering Chemistry.  (Washington, DC)  V.15-62,
   1923-70.  For publisher information, see CHMTBL.  Volume(issue)/page/year:
   30,592,1938
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2400 mg/kg/30D-I
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   IECHAD Industrial and Engineering Chemistry.  (Washington, DC)  V.15-62,
   1923-70.  For publisher information, see CHMTBL.  Volume(issue)/page/year:
   30,592,1938
 
                            *** END OF RECORD ***