*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HE1750000
CHEMICAL NAME           : 2,4,6,8-Decatetraenedioic acid,
                          4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1-
                          oxaspiro(2,5)oct-6-yl ester
CAS REGISTRY NUMBER     : 23110-15-8
OTHER CAS REGISTRY NOS. : 297-95-0
LAST UPDATED            : 199309
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C26-H34-O7
MOLECULAR WEIGHT        : 458.60
WISWESSER LINE NOTATION : BT3OTJ B C2UY
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Amebacilin
   * Amebacillin
   * Fugilin
   * Fugillin
   * Fumadil B
   * Fumagillin
   * Fumidil
   * Fumidil B
   * H-3
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
   eds., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 3,1834,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ANTCAO Antibiotics and Chemotherapy (Washington, DC).  (Washington, DC)
   V.1-12, 1951-62.  For publisher information, see CLMEA3.
   Volume(issue)/page/year: 1,54,1951
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 25 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H.,
   Paris, Masson et Cie, 1971  Volume(issue)/page/year: -,95,1971
 
                            *** END OF RECORD ***