*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HA5600000
CHEMICAL NAME           : Cytosine, 1-beta-D-arabino-furanosyl-,
                          2',3',5'-triacetate
CAS REGISTRY NUMBER     : 6742-07-0
LAST UPDATED            : 199606
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C15-H19-N3-O8
MOLECULAR WEIGHT        : 369.37
WISWESSER LINE NOTATION : T6NVNJ DZ A- BT5OTJ COV1 DOV1 E1OV1
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 1-beta-D-Arabinofuranosyl-2',3',5'-triacetate
   * Cytosine arabinoside triacetate
   * NSC-93150
   * 2(1H)-Pyrimidinone,  
   4-amino-1-(2,3,5-tri-O-acetyl-beta-D-arabinofuranosyl)-
   * Tri-O-acetylarabinosylcytosine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5010 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCIHL* Progress Report Submitted to the National Cancer Institute by
   Hazelton Laboratories, Inc. (Falls Church, VA)  Volume(issue)/page/year:
   -,353,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCIHL* Progress Report Submitted to the National Cancer Institute by
   Hazelton Laboratories, Inc. (Falls Church, VA)  Volume(issue)/page/year:
   -,353,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 680 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCIHL* Progress Report Submitted to the National Cancer Institute by
   Hazelton Laboratories, Inc. (Falls Church, VA)  Volume(issue)/page/year:
   -,353,1967
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg/5D-I
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   NCIHL* Progress Report Submitted to the National Cancer Institute by
   Hazelton Laboratories, Inc. (Falls Church, VA)  Volume(issue)/page/year:
   -,353,1967
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 750 mg/kg/15D-I
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Blood - changes in bone marrow (not otherwise specified)
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   NCIHL* Progress Report Submitted to the National Cancer Institute by
   Hazelton Laboratories, Inc. (Falls Church, VA)  Volume(issue)/page/year:
   -,353,1967
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 3 gm/kg/15D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes primarily in glomeruli
   Blood - thrombocytopenia
   Related to Chronic Data - death
REFERENCE :
   NCIHL* Progress Report Submitted to the National Cancer Institute by
   Hazelton Laboratories, Inc. (Falls Church, VA)  Volume(issue)/page/year:
   -,353,1967
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 750 mg/kg/15D-I
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   NCIHL* Progress Report Submitted to the National Cancer Institute by
   Hazelton Laboratories, Inc. (Falls Church, VA)  Volume(issue)/page/year:
   -,353,1967
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 49 umol/L
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 49,2551,1984
 
                            *** END OF RECORD ***