*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : HA5306000
CHEMICAL NAME           : (11)Cytochalasa-6(12),13,19-trien-1-one,
                          21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-
                          phenyl-, (7S,13E,16S,18S,19E,21R)-
CAS REGISTRY NUMBER     : 53760-19-3
LAST UPDATED            : 199107
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C30-H39-N-O5
MOLECULAR WEIGHT        : 493.70
WISWESSER LINE NOTATION : T56-11- 1A R AXVM GY JU PUTJ D1R& F1 GU1 HQ M1 OQ O1
                          ROV1
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   *   21-Acetoxy-7,18-dihydroxy-16,18-dimethyl-10-phenyl-(11)cytochalasa-6(12)
     ,13,19-triene-1-one
   * Cytochalasin-H
   * Kodocytochalasin-1
   * Paspalin
   * Paspalin P I
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 2,439,1980
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJEMAG Japanese Journal of Experimental Medicine.  (Kinokuniya Book-Stores
   of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581
   Webster St., San Francisco, CA 94115) V.7-    1928- Volume(issue)/page/year:
   48,105,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 12500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CJMIAZ Canadian Journal of Microbiology.  (National Research Council of
   Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 
     1954-  Volume(issue)/page/year: 22,1137,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 2341 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
REFERENCE :
   INDRBA Indian Drugs.  (Indian Drugs Manufacturers' Assoc., 102B, Poonam
   Chambers, Dr. A. B. Rd., Worli, Bombay 400 018, India)  V.1-    1963-
   Volume(issue)/page/year: 15,76,1978
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 500 ug/L
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 16,430,1978
 
                            *** END OF RECORD ***