*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GZ0635000
CHEMICAL NAME           : 5H-Cyclopropa(3,4)benz(1,2-e)azulen-5-one,
                          1,1a-alpha,1b-beta,4,4a,7a-alpha,7b,8,9,9a-
                          decahydro-4a-alpha,7b-alpha,9-beta,9a-alpha-tetrahydr
                          oxy-3-hydroxymethyl-1 ,1,6,8-alpha- tetramethyl-,
                          9-butyrate 9a-dodecanoate
CAS REGISTRY NUMBER     : 37415-56-8
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C36-H57-O8
MOLECULAR WEIGHT        : 617.93
COMPOUND DESCRIPTOR     : Tumorigen
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * 12-O-Butyroyl-phorboldodecanoate
   * Phorbol, 12-O-butyroyl-13-dodecanoate
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 ng
REACTION SEVERITY       : Mild
REFERENCE :
   85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer
   Congress," Chicago, Year Book Medical Pub., 1971  Volume(issue)/page/year:
   5,213,1970
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 12 mg/kg/12W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer
   Congress," Chicago, Year Book Medical Pub., 1971  Volume(issue)/page/year:
   5,213,1970
 
                            *** END OF RECORD ***