*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GZ0591910
CHEMICAL NAME           : 5H-Cyclopropa(3,4)benz(1,2-e)azulen-5-one,
                          1,1a-alpha,1b-beta,4,4a,7a-alpha,7b,8,9,9a-
                          decahydro-3-hydroxymethyl-4a-alpha,7b-alpha,9-beta,9a
                          -alpha-tetrahydroxy-1 ,1,6,8-alpha- tetramethyl-,
                          9a-acetate, 9-tetradeca-2,4,6,8-tetraenoate, (2Z,4E)-
CAS REGISTRY NUMBER     : 64604-09-7
BEILSTEIN REFERENCE NO. : 2319821
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C36-H48-O8
MOLECULAR WEIGHT        : 608.84
WISWESSER LINE NOTATION : L E3 B675 MV IUTJ BQ C1 DOV1U2U2U2U6 EOV1 F1 F1 J1Q
                          LQ N1
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 12-O-Tetradeca-2-cis,4-trans,6,8-tetraenoylphorbol-13-acetate
   * TI-8
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 19 mg/kg/48W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,4183,1979
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Administration onto the skin
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 400 nmol/kg
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 24,533,1979
 
                            *** END OF RECORD ***