*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GX9625000
CHEMICAL NAME           : Cyclooctanecarbamic acid,
                          1,1-bis(p-fluorophenyl)-2-propynyl ester
CAS REGISTRY NUMBER     : 20930-00-1
BEILSTEIN REFERENCE NO. : 3110210
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C24-H25-F2-N-O2
MOLECULAR WEIGHT        : 397.50
WISWESSER LINE NOTATION : L8TJ AMVOX1UU1&R DF&R DF
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * 1,1-Bis(4-fluorophenyl)-2-propynyl N-cyclooctyl carbamate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 617 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HarPN# Personal Communication from P.N. Harris, Eli Lily Co., Greenfield, IN
   46140. Oct. 21, 1974  Volume(issue)/page/year: 21OCT1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 456 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HarPN# Personal Communication from P.N. Harris, Eli Lily Co., Greenfield, IN
   46140. Oct. 21, 1974  Volume(issue)/page/year: 21OCT1974
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1900 mg/kg/66D-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   30,2881,1970
 
                            *** END OF RECORD ***