*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GW0175000
CHEMICAL NAME           : Cyclohexanol, methyl-
CAS REGISTRY NUMBER     : 25639-42-3
BEILSTEIN REFERENCE NO. : 1445998
REFERENCE               : 3-06-00-00073 (Beilstein Handbook Reference)
LAST UPDATED            : 199712
DATA ITEMS CITED        : 29
MOLECULAR FORMULA       : C7-H14-O
MOLECULAR WEIGHT        : 114.21
COMPOUND DESCRIPTOR     : Human
SYNONYMS/TRADE NAMES :
   * Hexahydrocresol
   * Hexahydromethylphenol
   * Methylcyclohexanol
   * Methylhexalin
   * Metylocykloheksanol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 500 ppm
TOXIC EFFECTS :
   Behavioral - antipsychotic
   Liver - other changes
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   TGNCDL "Handbook of Organic Industrial Solvents," 2nd ed., Chicago, National
   Assoc. of Mutual Casualty Companies, 1961 Volume(issue)/page/year: 2,55,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1660 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 25,415,1943
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 25,415,1943
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co.,
   1956-59  Volume(issue)/page/year: 1,194,1955
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 6800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co.,
   1956-59  Volume(issue)/page/year: 1,194,1955

                              *** REVIEWS ***
 
   ACGIH TLV-TWA 234 mg/m3 (50 ppm)
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   MSHA STANDARD-air:TWA 50 ppm (235 mg/m3)
   DTLWS* "Documentation of the Threshold Limit Values for Substances in
   Workroom Air," Supplements. For publisher information, see 85INA8.
   Volume(issue)/page/year: 3,23,1973

   OSHA PEL (Gen Indu):8H TWA 100 ppm (470 mg/m3)
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1910.1000,1994

   OSHA PEL (Construc):8H TWA 100 ppm (470 mg/m3)
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1926.55,1994

   OSHA PEL (Shipyard):8H TWA 100 ppm (470 mg/m3)
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1915.1000,1993

   OSHA PEL (Fed Cont):8H TWA 100 ppm (470 mg/m3)
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   41,50-204.50,1994

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-AUSTRALIA:TWA 50 ppm (235 mg/m3) JAN 1993
   
   OEL-BELGIUM:TWA 50 ppm (234 mg/m3) JAN 1993
   
   OEL-DENMARK:TWA 50 ppm (235 mg/m3) JAN 1993
   
   OEL-FINLAND:TWA 50 ppm (235 mg/m3);STEL 75 ppm (355 mg/m3) JAN 1993
   
   OEL-FRANCE:TWA 50 ppm (235 mg/m3) JAN 1993
   
   OEL-GERMANY:TWA 50 ppm (235 mg/m3) JAN 1993
   
   OEL-JAPAN:TWA 50 ppm (230 mg/m3) JAN 1993
   
   OEL-THE NETHERLANDS:TWA 50 ppm (235 mg/m3) JAN 1993
   
   OEL-THE PHILIPPINES:TWA 100 ppm (470 mg/m3) JAN 1993
   
   OEL-POLAND:TWA 50 mg/m3 JAN 1993
   
   OEL-RUSSIA:TWA 50 ppm JAN 1993
   
   OEL-SWITZERLAND:TWA 50 ppm (235 mg/m3);STEL 100 ppm (470 mg/m3) JAN 1993
   
   OEL-TURKEY:TWA 100 ppm (470 mg/m3) JAN 1993
   
   OEL-UNITED KINGDOM:TWA 50 ppm (235 mg/m3);STEL 75 ppm JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO METHYLCYCLOHEXANOL-air:10H TWA 50 ppm
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

                          *** STATUS IN U.S. ***
 
   NIOSH Analytical Method, 1994: Methylcyclohexanol, 1404

 
                            *** END OF RECORD ***