*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GT9200000
CHEMICAL NAME           : 2,20-Cycloaspidospermidine-3-carboxylic acid,
                          6,7-didehydro-, methyl ester, dihydrochloride,
                          (2-alpha,3-beta,5-alpha,12-beta,19-alpha,20R)-
CAS REGISTRY NUMBER     : 976-78-3
LAST UPDATED            : 198806
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C21-H24-N2-O2.2Cl-H
MOLECULAR WEIGHT        : 409.39
WISWESSER LINE NOTATION : T C6 B5665 2AB S BX IM QN NU JH&&TTTJ KVO1 M2 &GH 2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Vindolinine dihydrochloride
   * Vindolinine, dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   33GVAL "Catharanthus Alkaloids," Taylor, W.I., and N.R. Farnsworth, eds.,
   New York, Marcel Dekker, 1975  Volume(issue)/page/year: -,73,1975
 
                            *** END OF RECORD ***