*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GS2169000
CHEMICAL NAME : Cuprate(4-),
(mu-((3,3'-((3,3'-dihydroxy(1,1'-biphenyl)-4,4'-diyl)
bis(azo))bis(5-amino-
4-hydroxy-2,7-naphthalenedisulfonato))(8-)))di-,
tetrasodium
CAS REGISTRY NUMBER : 28407-37-6
OTHER CAS REGISTRY NOS. : 10401-50-0
LAST UPDATED : 199710
DATA ITEMS CITED : 17
MOLECULAR FORMULA : C32-H16-Cu2-N6-O16-S4.4Na
MOLECULAR WEIGHT : 1087.82
WISWESSER LINE NOTATION : L66J BQ DSWO HSWO CNUNR BQ DR CQ DNUN- CL66J DSWO
HSWO &-NA- 4
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Amanil Supra Blue 9GL
* C.I. 24401
* C.I. Direct Blue 218
* Fastusol Blue 9GLP
* NCI C60877
* Pontamine Bond Blue B
* Pontamine Fast Blue 7GLN
* Solantine Blue 10GL
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3290 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS 215154
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 3920 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS 215154
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS 215154
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 25200 mg/kg/14D-C
TOXIC EFFECTS :
Cardiac - changes in heart weight
Endocrine - changes in thymus weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-430,1994
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 45500 mg/kg/13W-C
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - changes in bladder weight
Blood - pigmented or nucleated red blood cells
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-430,1994
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 50 gm/kg/14D-C
TOXIC EFFECTS :
Cardiac - changes in heart weight
Liver - changes in liver weight
Endocrine - changes in thymus weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-430,1994
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 109 gm/kg/13W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-430,1994
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 438 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-430,1994
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 876 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-430,1994
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 1 mg/plate
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 22,413,1980
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2161
No. of Facilities: 60 (estimated)
No. of Industries: 4
No. of Occupations: 9
No. of Employees: 2461 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M2161
No. of Facilities: 530 (estimated)
No. of Industries: 10
No. of Occupations: 13
No. of Employees: 12290 (estimated)
No. of Female Employees: 4390 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NTP Carcinogenesis studies (feed);clear evidence:mouse
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-430,94
NTP Carcinogenesis studies (feed);some evidence:rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-430,94
*** END OF RECORD ***