*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GS2168800
CHEMICAL NAME           : Cuprate(1-),
                          bis(2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicoti
                          nato)aqua-, polymers
CAS REGISTRY NUMBER     : 62511-77-7
LAST UPDATED            : 198606
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : (C26-H14-F6-N4-O4)n.nCu.nH2-O
WISWESSER LINE NOTATION : T6NJ BMR CXFFF& CVO 2 &-CU- &QH
COMPOUND DESCRIPTOR     : Drug
                          Organometallic
SYNONYMS/TRADE NAMES :
   * Copper(II) niflumate
   * Niflumic acid, copper chelate, hydrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 650 mg/kg
TOXIC EFFECTS :
   Musculoskeletal - joints
   Tumorigenic - active as anti-cancer agent
   Biochemical - Metabolism (Intermediary) - effect on inflammation or
   mediation of inflammation
REFERENCE :
   PMDCAY Progress in Medical Chemistry.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1961- Volume(issue)/page/year:
   15,211,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Musculoskeletal - joints
   Tumorigenic - active as anti-cancer agent
   Biochemical - Metabolism (Intermediary) - effect on inflammation or
   mediation of inflammation
REFERENCE :
   PMDCAY Progress in Medical Chemistry.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1961- Volume(issue)/page/year:
   15,211,1977
 
                            *** END OF RECORD ***