*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GR0270000
CHEMICAL NAME           : Crystallomycin, sodium salt
LAST UPDATED            : 199509
DATA ITEMS CITED        : 9
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ANTBAL Antibiotiki.  (Moscow, USSR)  V.1-29, 1956-84.  For publisher
   information, see AMBIEH.  Volume(issue)/page/year: 4(4),63,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 109 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ATBTAR Antibiotics (USSR). English translation of ANTBAL.  (New York, NY)
   V.4, 1959. Discontinued.  Volume(issue)/page/year: 4,448,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 220 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ATBTAR Antibiotics (USSR). English translation of ANTBAL.  (New York, NY)
   V.4, 1959. Discontinued.  Volume(issue)/page/year: 4,448,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 124 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ATBTAR Antibiotics (USSR). English translation of ANTBAL.  (New York, NY)
   V.4, 1959. Discontinued.  Volume(issue)/page/year: 4,448,1959
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ATBTAR Antibiotics (USSR). English translation of ANTBAL.  (New York, NY)
   V.4, 1959. Discontinued.  Volume(issue)/page/year: 4,448,1959
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ATBTAR Antibiotics (USSR). English translation of ANTBAL.  (New York, NY)
   V.4, 1959. Discontinued.  Volume(issue)/page/year: 4,448,1959
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ATBTAR Antibiotics (USSR). English translation of ANTBAL.  (New York, NY)
   V.4, 1959. Discontinued.  Volume(issue)/page/year: 4,448,1959
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 225 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ATBTAR Antibiotics (USSR). English translation of ANTBAL.  (New York, NY)
   V.4, 1959. Discontinued.  Volume(issue)/page/year: 4,448,1959
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 1200 mg/kg/4W-I
TOXIC EFFECTS :
   Blood - pigmented or nucleated red blood cells
   Blood - changes in erythrocyte (RBC) count
   Related to Chronic Data - death
REFERENCE :
   ATBTAR Antibiotics (USSR). English translation of ANTBAL.  (New York, NY)
   V.4, 1959. Discontinued.  Volume(issue)/page/year: 4,448,1959
 
                            *** END OF RECORD ***