*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GQ1255000
CHEMICAL NAME           : Crotonamide,
                          N-(p-((3-cyclohexyl-2-imino-1-imidazolidinyl)sulfonyl
                          )phenethyl)-
LAST UPDATED            : 199406
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C21-H30-N4-O3-S
MOLECULAR WEIGHT        : 418.61
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 2-Butenamide,  
   N-(2-(4-((3-cyclohexyl-2-imino-1-imidazolidinyl)sulfonyl)phenyl)ethyl)-,  
   (E)-
   * CGP 11112
   *   1-(p-(2-(Crotonylamino)ethyl)phenylsulfonyl)-3-cyclohexyl-2-iminoimidazo
     lidine
   *   N-(p-((3-Cyclohexyl-2-imino-1-imidazolidinyl)sulfonyl)phenethyl)crotonam
     ide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 34,247,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 34,247,1984
 
                            *** END OF RECORD ***