*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GH0895000
CHEMICAL NAME           : Colchicine, N-methyl-17,17,17-trifluoro-
CAS REGISTRY NUMBER     : 71295-35-7
LAST UPDATED            : 199409
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C23-H24-F3-N-O6
MOLECULAR WEIGHT        : 467.48
WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 EO1 JN1&VXFFF NO1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * N-Methyl-17,17,17-trifluorocolchicine
   * N-(Trifluoroacetyl)demecolchine
   * N-(Trifluoroacetyl)demecolcine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4114 ug/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 24,257,1981
 
                            *** END OF RECORD ***