*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GH0880500
CHEMICAL NAME           : Colchicine, 3-O-demethyl-
CAS REGISTRY NUMBER     : 7336-33-6
LAST UPDATED            : 199112
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C21-H23-N-O6
MOLECULAR WEIGHT        : 385.45
WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 EQ JMV1 NO1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Acetamide,  
   N-(5,6,7,9-tetrahydro-3-hydroxy-1,2,10-trimethoxy-9-oxobenzo(a)heptalen-  
   7-yl)-, (S)
   * Colchicine, O(sup 3)-demethyl-
   * Colchicine, 2-demethyl-
   * 3-O-Demethylcolchicine
   * 3-Desmethylcolchicine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 570 ug/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 24,636,1981
 
                            *** END OF RECORD ***