*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GH0878800
CHEMICAL NAME           : Colchicine, 10-demethoxy-10-methylthio-
CAS REGISTRY NUMBER     : 2730-71-4
LAST UPDATED            : 199409
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C22-H25-N-O5-S
MOLECULAR WEIGHT        : 415.54
WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 EO1 JMV1 NS1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Acetamide,  
   N-(5,6,7,9-tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo(a)hept  
   alen-7-yl)-
   * Colchicine, 10-thio-
   * 10-Demethoxy-10-methylthiocolchicine
   * Thiocolchicine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 997 ug/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 24,636,1981
 
                            *** END OF RECORD ***