*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GH0600000
CHEMICAL NAME           : Colchiceine, N-deacetyl-N-methyl-
CAS REGISTRY NUMBER     : 518-11-6
LAST UPDATED            : 198712
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C20-H23-N-O5
MOLECULAR WEIGHT        : 357.44
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Benzo(a)heptalen-9(5H)-one,  
   6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-, (S)-
   * Colchameine
   * Demecolceine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   PHTXA6 Pharmacology and Toxicology.  English translation of FATOAO.  (New
   York, NY)  V.20-22, 1957-59.  Discontinued.  Volume(issue)/page/year:
   20,284,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   PHTXA6 Pharmacology and Toxicology.  English translation of FATOAO.  (New
   York, NY)  V.20-22, 1957-59.  Discontinued.  Volume(issue)/page/year:
   20,284,1957
 
                            *** END OF RECORD ***