*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : FZ4040000
CHEMICAL NAME           : Cholanthrene, 3-methyl-11,12-epoxy-
CAS REGISTRY NUMBER     : 67195-51-1
LAST UPDATED            : 199410
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C21-H14-O
MOLECULAR WEIGHT        : 282.35
WISWESSER LINE NOTATION : T D3 G6 C6665 1A U EO&&&&&TJ R1
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Benz(7,8)aceanthryleno(9,10-b)oxirene, 3-methyl-
   * 11,12-Epoxy-3-methylcholanthrene
   * MCA-11,12-epoxide
   * MCA-11,12-oxide
   * 3-Methylcholanthrene-11,12-epoxide
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 226 ug/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   58,1051,1977
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 ug/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   45,2600,1985
 
TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 23400 nmol/L
REFERENCE :
   NNBYA7 Nature (London), New Biology.  (Basingstoke, Hants., UK)  V.229-246,
   1971-73.  For publisher information, see NATUAS.  Volume(issue)/page/year:
   234,186,1971
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 750 ug/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   32,716,1972
 
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 5 mmol/L
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 68,3195,1971
 
                            *** END OF RECORD ***