*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : FL4725000
CHEMICAL NAME           : Cevane-3-beta,4-beta,7-alpha,14,15-alpha,16-beta,20-h
                          eptol, 4,9-epoxy-
CAS REGISTRY NUMBER     : 508-65-6
BEILSTEIN REFERENCE NO. : 0099115
REFERENCE               : 5-21-13-00706 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C27-H43-N-O8
MOLECULAR WEIGHT        : 509.71
WISWESSER LINE NOTATION : T J6 H6 E6 D5665/TC& 3ATU C& ON TX C&OTJ CQ EQ FQ GQ
                          IQ I1 M1 U1 A&Q B&Q
SYNONYMS/TRADE NAMES :
   * Cevane-3,4,7,14,15,16,20-heptol, 4,9-epoxy-,  
   (3-beta,4-alpha,7-alpha,5-alpha,16-beta)-
   * Germin
   * Germine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - excitement
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 189,397,1938
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 113,89,1955
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - excitement
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 189,397,1938

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   LYPHAD Lyon Pharmaceutique.  (Medipharly, 12, rue de la Barre, 69002 Lyons,
   France)  V.1-    1950-  Volume(issue)/page/year: 26,5,1975

 
                            *** END OF RECORD ***