*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : FH8408900
CHEMICAL NAME           : Carica papaya, seed extract
LAST UPDATED            : 198910
DATA ITEMS CITED        : 3
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Natural Product
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3500 mg/kg
SEX/DURATION            : female 1-7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   PLMEAA Planta Medica.  (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart
   1, Fed. Rep. Ger.) V.1-    1953-  Volume(issue)/page/year: 26,391,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2 mg/kg
SEX/DURATION            : male 5 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   AEFTAA Acta Europaea Fertilitatis.  (COFESE Eds., Piazzale Ungheria 73,
   90141 Palermo, Italy) V.1-    1969-  Volume(issue)/page/year: 14,425,1983
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1600 ug/kg
SEX/DURATION            : male 4 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   AEFTAA Acta Europaea Fertilitatis.  (COFESE Eds., Piazzale Ungheria 73,
   90141 Palermo, Italy) V.1-    1969-  Volume(issue)/page/year: 14,425,1983
 
                            *** END OF RECORD ***