*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : FH5425000
CHEMICAL NAME           : 5-beta-Card-20(22)-enolide,
                          3-beta,5,14-trihydroxy-19-oxo-
CAS REGISTRY NUMBER     : 66-28-4
BEILSTEIN REFERENCE NO. : 0097859
REFERENCE               : 5-18-05-00126 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C23-H32-O6
MOLECULAR WEIGHT        : 404.55
WISWESSER LINE NOTATION : L E5 B666TJ AVH E1 IQ MQ OQ F- DT5OV EHJ
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Antibiotic XS-89
   * Apocynamarin
   * Card-20(22)-enolide, 3,5,14-trihydroxy-19-oxo-, (3-beta,5-beta)-
   * Convallatoxigenin
   * Corchorgenin
   * Corchorin
   * Corchoside A aglycon
   * Corchsularin
   * Cyanotoxin
   * Cymarigenin
   * Cynotoxin
   * Erysimupicrone
   * Erysimupikron
   * 5-beta-Hydroxy-19-oxodigitoxigenin
   * NSC-86078
   * 19-Oxo-cardogenen-(20:22)-triol-(3-beta,5,14)
   * Strophanthidin
   * k-Strophanthidin
   * K-Strophanthidin
   * Strophanthidine
   * k-Strophanthidine
   * Strophanthidin K
   * 3,5,14-Trihydroxy-19-oxocard-20(22)-enolide
   * 3-beta,5,14-Trihydroxy-19-oxo-5-beta-card-20(22)-enolide
   * 3-beta,5,14-Trioxy-19-oxo-carden-(20:22)-olid
   * 3-beta,5,14-Trioxy-19-oxo-digen-(20:22)-olid
   * XS-89
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 330 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 8(2),224,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 63 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,908,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 224 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 103,420,1951
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 260 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 148,471,1964
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 110 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 185,329,1937
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 240 ug/kg
TOXIC EFFECTS :
   Cardiac - cardiomyopathy including infarction
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 155,251,1965
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 526 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APJUA8 Acta Pharmaceutica Jugoslavica.  (FDH, Masarykova 2, 41000 Zagreb,
   Yugoslavia)  V.1-41, 1951-1991.  Volume(issue)/page/year: 24,179,1974

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   CHIMAD Chimia.  (Postfach 2027, CH-4001 Basel, Switzerland)  V.1-    1947-
   Volume(issue)/page/year: 5,93,1951

 
                            *** END OF RECORD ***