*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : AI4930000
CHEMICAL NAME : Acetic acid, isopropyl ester
CAS REGISTRY NUMBER : 108-21-4
BEILSTEIN REFERENCE NO. : 1740761
REFERENCE : 4-02-00-00141 (Beilstein Handbook Reference)
LAST UPDATED : 199806
DATA ITEMS CITED : 36
MOLECULAR FORMULA : C5-H10-O2
MOLECULAR WEIGHT : 102.15
WISWESSER LINE NOTATION : 1Y1&OV1
COMPOUND DESCRIPTOR : Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acetate d'isopropyle
* Acetic acid, 1-methylethyl ester
* 2-Acetoxypropane
* Isopropile (acetato di)
* Isopropylacetaat
* Isopropylacetat
* Isopropyl acetate
* Isopropyl (acetate d')
* Isopropylester kyseliny octove
* 2-Propyl acetate
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Human
DOSE/DURATION : 200 ppm/15M
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 28,262,1946
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,354,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 200 ppm
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year: 21,28,1960
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human
DOSE/DURATION : 200 ppm
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - conjunctive irritation
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 28,262,1946
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 3/24/1970
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 50600 mg/m3/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
20,364,1959
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >174 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JSGRA2 Journal of Surgical Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1961- Volume(issue)/page/year: 53,572,1992
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 174 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JSGRA2 Journal of Surgical Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1961- Volume(issue)/page/year: 53,572,1992
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 6946 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73.
For publisher information, see IOHSA5. Volume(issue)/page/year: 41,31,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >20 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954
*** REVIEWS ***
ACGIH TLV-STEL 1290 mg/m3 (310 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 1040 mg/m3 (250 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year: 21,28,1960
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 250 ppm (950 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,141,1971
OSHA PEL (Gen Indu):8H TWA 250 ppm (950 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 250 ppm (950 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 250 ppm (950 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 250 ppm (950 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 200 ppm (950 mg/m3);STEL 310 ppm (1185 mg/m3) JAN 1993
OEL-BELGIUM:TWA 250 ppm (1040 mg/m3);STEL 310 ppm (1290 mg/m3) JAN 1993
OEL-DENMARK:TWA 200 ppm (840 mg/m3) JAN 1993
OEL-FRANCE:TWA 250 ppm (950 mg/m3);STEL 300 ppm (1140 mg/m3) JAN 1993
OEL-GERMANY:TWA 200 ppm (840 mg/m3) JAN 1993
OEL-HUNGARY:TWA 400 mg/m3;STEL 800 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 250 ppm (950 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 250 ppm (950 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 200 ppm (840 mg/m3);STEL 400 ppm JAN 1993
OEL-UNITED KINGDOM:TWA 250 ppm (950 mg/m3);STEL 310 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 40984
No. of Facilities: 10160 (estimated)
No. of Industries: 103
No. of Occupations: 67
No. of Employees: 84001 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 40984
No. of Facilities: 8643 (estimated)
No. of Industries: 85
No. of Occupations: 68
No. of Employees: 159819 (estimated)
No. of Female Employees: 50913 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Isopropyl acetate, 1454
*** END OF RECORD ***