*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : FD8940400
CHEMICAL NAME           : Carbanilic acid, o-(heptyloxy)-,
                          2-(diethylamino)-1-methylethyl ester, hydrochloride
CAS REGISTRY NUMBER     : 68931-03-3
LAST UPDATED            : 199406
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C21-H36-N2-O3.Cl-H
MOLECULAR WEIGHT        : 401.05
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * BK-95
   * Carbamic acid, (2-(heptyloxy)phenyl)-, 2-(diethylamino)-1-methylethyl  
   ester, hydrochloride
   * Carbisocaine
   * Carbizocaine hydrochloride
   * o-(Heptyloxy)carbanilic acid 2-(diethylamino)-1-methylethyl ester  
   hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 63 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DECRDP Drugs under Experimental and Clinical Research.  (Bioscience
   Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland)  V.1-    1977-
   Volume(issue)/page/year: 12,845,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 380 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DECRDP Drugs under Experimental and Clinical Research.  (Bioscience
   Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland)  V.1-    1977-
   Volume(issue)/page/year: 12,845,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 16 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DECRDP Drugs under Experimental and Clinical Research.  (Bioscience
   Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland)  V.1-    1977-
   Volume(issue)/page/year: 12,845,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 48 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DMDIEQ Drug Metabolism and Drug Interactions.  (Freund Publishing House,
   Suite 500, Chesham House, 150 Regent Street, London, W1R 5FA, United
   Kingdom)  V.6-    1988-  Volume(issue)/page/year: 9,321,1991
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CKFRAY Ceskoslovenska Farmacie.  (PNS-Ustredni Expedice a Dovoz Tisku,
   Kafkova 19, 160 00 Prague 6, Czechoslovakia)  V.1-    1952-
   Volume(issue)/page/year: 27,167,1978
 
                            *** END OF RECORD ***