*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : FD7688000
CHEMICAL NAME           : Carbanilic acid, p-carboxy-,
                          1,1'-trimethylenebis(2-(diethylamino)ethyl) ester,
                          dihydrochloride
LAST UPDATED            : 198606
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C31-H44-N4-O8.2Cl-H
MOLECULAR WEIGHT        : 673.71
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * p-Carboxycarbanilic acid 1,1'-trimethylenebis(2-(diethylamino)ethyl)  
   ester dihydrochloride
   * McN-100 dihydrochloride
   * Tridiurecaine dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Behavioral - sleep
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 99,421,1950
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Vascular - BP elevation not characterized in autonomic section
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 99,421,1950
 
                            *** END OF RECORD ***