*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : FD0808000
CHEMICAL NAME           : Carbamic acid,
                          (5-(phenylsulfinyl)-1H-benzimidazol-2-yl)-, methyl
                          ester
CAS REGISTRY NUMBER     : 53716-50-0
BEILSTEIN REFERENCE NO. : 0761290
LAST UPDATED            : 199612
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C15-H13-N3-O3-S
MOLECULAR WEIGHT        : 315.37
WISWESSER LINE NOTATION : T56 BM DNJ CMVO1 HSO&R
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 2-Benzimidazolecarbamic acid, 5-(phenylsulfinyl)-, methyl ester
   * Fenbendazole sulfoxide
   * HOE 8105
   * Methyl 5-(phenylsulfinyl)-2-benzimidazolecarbamate
   * Methyl (5-phenylsulfinyl)-1H-benzimidazol-2-yl carbamate
   * OFDZ
   * Oxfendazole
   * 5-(Phenylsulfinyl)-2-benzimidazolecarbamic acid methyl ester
   * (5-(Phenylsulfinyl)-1H-benzimidazol-2-yl)carbamic acid methyl ester
   * 5-Phenylsulfinyl-2-carbomethoxyaminobenzimidazole
   * Repidose
   * RS-8858
   * Synanthic
   * Systamex
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >6400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 18,1164,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >6400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 18,1164,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >1600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 18,1164,1975
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 126 mg/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   RMVEAG Recueil de Medecine Veterinaire.  (Masson Pub. USA, Inc., Year Book
   Medical Pub., 35 E. Wacker Dr., Chicago IL 60601)  V.1-    1824-
   Volume(issue)/page/year: 153,639,1977
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - domestic
DOSE                    : 22500 ug/kg
SEX/DURATION            : female 17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   RMVEAG Recueil de Medecine Veterinaire.  (Masson Pub. USA, Inc., Year Book
   Medical Pub., 35 E. Wacker Dr., Chicago IL 60601)  V.1-    1824-
   Volume(issue)/page/year: 153,639,1977
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - domestic
DOSE                    : 22500 ug/kg
SEX/DURATION            : female 17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
   Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
   RMVEAG Recueil de Medecine Veterinaire.  (Masson Pub. USA, Inc., Year Book
   Medical Pub., 35 E. Wacker Dr., Chicago IL 60601)  V.1-    1824-
   Volume(issue)/page/year: 153,639,1977
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 2 mg/L
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 31,505,1976
 
                            *** END OF RECORD ***