*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : FD0406800
CHEMICAL NAME           : Carbamic acid, (3-(pentyloxy)phenyl)-,
                          2-(1-pyrrolidinyl)cyclohexyl ester,
                          monohydrochloride, trans-(+-)-
CAS REGISTRY NUMBER     : 77656-21-4
LAST UPDATED            : 199403
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C22-H34-N2-O3.Cl-H
MOLECULAR WEIGHT        : 411.04
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Pentacaine hydrochloride
   * Pentakain hydrochlorid
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 47 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DMDIEQ Drug Metabolism and Drug Interactions.  (Freund Publishing House,
   Suite 500, Chesham House, 150 Regent Street, London, W1R 5FA, United
   Kingdom)  V.6-    1988-  Volume(issue)/page/year: 9,321,1991
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 150 mg/kg
SEX/DURATION            : female 6-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   CEFYAD Ceskoslovenska Fysiologie.  (Academia, Vodickova 40, 112 29 Prague 1,
   Czechoslovakia) V.1-    1952-  Volume(issue)/page/year: 38,278,1989
 
                            *** END OF RECORD ***