*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : FD0406500
CHEMICAL NAME           : Carbamic acid, (3-(pentyloxy)phenyl)-,
                          2-(1-pyrrolidinyl)cyclohexyl ester, trans-(+-)-
CAS REGISTRY NUMBER     : 104485-01-0
LAST UPDATED            : 199503
DATA ITEMS CITED        : 12
MOLECULAR FORMULA       : C22-H34-N2-O3
MOLECULAR WEIGHT        : 374.58
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Pentacaine
   * Pentakain
   * trans-(+-)-2-(1-Pyrrolidinyl)cyclohexyl (3-(pentyloxy)phenyl)carbamate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1030 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAOBAS Farmaceuticky Obzor.  Pharmaceutical Review.  (PNS - Ustredna
   Expedicia a Dovoz Tlace, Gottwaldovo nam. 6, 813 81 Bratislava,
   Czechoslovakia)  V.30-    1961-  Volume(issue)/page/year: 45,355,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAOBAS Farmaceuticky Obzor.  Pharmaceutical Review.  (PNS - Ustredna
   Expedicia a Dovoz Tlace, Gottwaldovo nam. 6, 813 81 Bratislava,
   Czechoslovakia)  V.30-    1961-  Volume(issue)/page/year: 45,355,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 283 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAOBAS Farmaceuticky Obzor.  Pharmaceutical Review.  (PNS - Ustredna
   Expedicia a Dovoz Tlace, Gottwaldovo nam. 6, 813 81 Bratislava,
   Czechoslovakia)  V.30-    1961-  Volume(issue)/page/year: 45,355,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 11800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAOBAS Farmaceuticky Obzor.  Pharmaceutical Review.  (PNS - Ustredna
   Expedicia a Dovoz Tlace, Gottwaldovo nam. 6, 813 81 Bratislava,
   Czechoslovakia)  V.30-    1961-  Volume(issue)/page/year: 45,355,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 790 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAOBAS Farmaceuticky Obzor.  Pharmaceutical Review.  (PNS - Ustredna
   Expedicia a Dovoz Tlace, Gottwaldovo nam. 6, 813 81 Bratislava,
   Czechoslovakia)  V.30-    1961-  Volume(issue)/page/year: 45,355,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAOBAS Farmaceuticky Obzor.  Pharmaceutical Review.  (PNS - Ustredna
   Expedicia a Dovoz Tlace, Gottwaldovo nam. 6, 813 81 Bratislava,
   Czechoslovakia)  V.30-    1961-  Volume(issue)/page/year: 45,355,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 122 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAOBAS Farmaceuticky Obzor.  Pharmaceutical Review.  (PNS - Ustredna
   Expedicia a Dovoz Tlace, Gottwaldovo nam. 6, 813 81 Bratislava,
   Czechoslovakia)  V.30-    1961-  Volume(issue)/page/year: 45,355,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAOBAS Farmaceuticky Obzor.  Pharmaceutical Review.  (PNS - Ustredna
   Expedicia a Dovoz Tlace, Gottwaldovo nam. 6, 813 81 Bratislava,
   Czechoslovakia)  V.30-    1961-  Volume(issue)/page/year: 45,355,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >60 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAOBAS Farmaceuticky Obzor.  Pharmaceutical Review.  (PNS - Ustredna
   Expedicia a Dovoz Tlace, Gottwaldovo nam. 6, 813 81 Bratislava,
   Czechoslovakia)  V.30-    1961-  Volume(issue)/page/year: 45,355,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2950 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAOBAS Farmaceuticky Obzor.  Pharmaceutical Review.  (PNS - Ustredna
   Expedicia a Dovoz Tlace, Gottwaldovo nam. 6, 813 81 Bratislava,
   Czechoslovakia)  V.30-    1961-  Volume(issue)/page/year: 45,355,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 58 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAOBAS Farmaceuticky Obzor.  Pharmaceutical Review.  (PNS - Ustredna
   Expedicia a Dovoz Tlace, Gottwaldovo nam. 6, 813 81 Bratislava,
   Czechoslovakia)  V.30-    1961-  Volume(issue)/page/year: 45,355,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 105 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAOBAS Farmaceuticky Obzor.  Pharmaceutical Review.  (PNS - Ustredna
   Expedicia a Dovoz Tlace, Gottwaldovo nam. 6, 813 81 Bratislava,
   Czechoslovakia)  V.30-    1961-  Volume(issue)/page/year: 45,355,1976
 
                            *** END OF RECORD ***