*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : FC2150000
CHEMICAL NAME           : Carbamic acid, methyldithio-, sodium salt, dihydrate
CAS REGISTRY NUMBER     : 6734-80-1
LAST UPDATED            : 199610
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C2-H4-N-S2.Na.2H2-O
MOLECULAR WEIGHT        : 165.22
WISWESSER LINE NOTATION : SUYSHM1 &-NA- &QH &QH
COMPOUND DESCRIPTOR     : Agricultural Chemical
SYNONYMS/TRADE NAMES :
   * Carbamodithioic acid, methyl-, monosodium salt, dihydrate
   * Metham dihydrate
   * Methyldithiokarbaman sodny dihydrat
   * N 869
   * Sodium N-methyldithiocarbamate dihydrate
   * Vaporooter
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 108 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCOC** Pesticide Chemicals Official Compendium, Association of the American
   Pesticide Control Officials, Inc., 1966.  (Topeka, KS)
   Volume(issue)/page/year: -,1047,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 285 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer
   Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R.,
   Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971  Volume(issue)/page/year:
   -,121,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 45(5),29,1980
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4200 mg/kg/14D-I
TOXIC EFFECTS :
   Endocrine - changes in thymus weight
   Blood - changes in bone marrow (not otherwise specified)
   Immunological Including Allergic - decrease in cellular immune response
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   18,40,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1200 mg/kg/4D-I
TOXIC EFFECTS :
   Endocrine - changes in spleen weight
   Endocrine - changes in thymus weight
   Immunological Including Allergic - decrease in cellular immune response
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   18,40,1992

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - A1593
       No. of Facilities: 52 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 4784 (estimated)

 
                            *** END OF RECORD ***